Predictions for positions 1 through 100
Threshold for intolerance is 0.05.
Amino acid color code: nonpolar, uncharged polar, basic, acidic.
Capital letters indicate amino acids appearing in the alignment, lower case letters result from prediction.
'Seq Rep' is the fraction of sequences that
contain one of the basic amino acids. A low fraction indicates the position is either severely gapped or unalignable and has little information. Expect poor prediction at these positions.
Predict Not Tolerated |
Position | Seq Rep |
Predict Tolerated |
| y | w | v | t | s | r | q | n | m | l | k | i | h | g | f | e | d | c | a | 1P | 0.85 | P | | | | | | | | | | | | | | | | | | | |
| | c | w | f | m | i | y | v | l | h | r | g | t | n | s | p | a | k | d | 2Q | 0.95 | E | Q | | | | | | | | | | | | | | | | | | |
| | | | | | d | h | n | e | c | p | g | q | r | k | s | w | t | a | 3I | 0.95 | m | Y | V | L | F | I | | | | | | | | | | | | | | |
| | | | | w | f | y | h | m | c | r | e | l | i | q | g | k | d | v | 4T | 0.95 | n | a | P | S | T | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | k | i | h | g | f | e | d | c | a | 5L | 0.95 | L | | | | | | | | | | | | | | | | | | | |
| | h | m | c | q | i | r | e | k | v | n | d | l | p | t | y | g | f | a | 6W | 0.95 | S | W | | | | | | | | | | | | | | | | | | |
| | | c | w | d | f | m | i | y | v | g | p | s | h | n | a | l | t | e | 7Q | 0.95 | K | Q | R | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | q | p | n | m | l | k | i | h | g | f | e | d | c | a | 8R | 1.00 | R | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | n | m | l | k | i | h | g | f | e | d | c | a | 9P | 1.00 | P | | | | | | | | | | | | | | | | | | | |
| | | | h | d | w | n | p | q | e | c | r | g | s | k | y | t | a | f | 10L | 1.00 | M | I | V | L | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | w | c | f | d | y | m | g | h | 11V | 1.00 | p | n | s | t | l | a | q | I | E | R | K | V | | | | | | | | |
| | | | | | | | | | | | | | w | c | f | m | y | i | 12T | 1.00 | h | v | g | l | d | n | P | s | A | q | E | K | R | T | | | | | | |
| | | | | | g | w | h | y | d | n | r | q | f | e | k | s | p | m | 13I | 1.00 | t | l | C | I | A | V | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | 14K | 1.00 | C | w | p | d | m | e | q | K | n | g | R | t | I | S | v | a | H | l | F | Y |
| | | h | q | w | p | d | n | e | c | r | s | k | g | y | a | t | m | f | 15I | 1.00 | L | V | I | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | w | c | m | f | i | y | l | v | 16G | 1.00 | r | h | t | p | s | a | k | G | q | n | D | E | | | | | | | | |
| | | | w | m | i | f | c | y | l | r | h | p | q | t | k | a | V | n | 17G | 1.00 | E | D | S | G | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | w | 18Q | 1.00 | c | f | y | m | g | d | p | n | e | H | l | i | s | r | a | k | T | V | Q | |
| | | | | | | | | | | | | | | | | | w | h | 19L | 1.00 | y | f | m | r | q | c | e | d | k | i | n | L | v | P | g | S | T | A | | |
| | | | | | | | w | h | g | d | y | n | r | q | e | s | p | f | 20K | 1.00 | m | C | t | a | K | l | I | V | | | | | | | | | | | | |
| | | | c | w | f | m | i | y | v | g | h | p | s | d | l | n | t | a | 21E | 1.00 | Q | R | K | E | | | | | | | | | | | | | | | | |
| | w | h | y | d | n | f | r | q | m | e | k | c | p | g | l | s | t | i | 22A | 1.00 | V | A | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | k | i | h | g | f | e | d | c | a | 23L | 1.00 | L | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | k | i | h | g | f | e | d | c | a | 24L | 1.00 | L | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | g | f | e | c | a | 25D | 1.00 | D | | | | | | | | | | | | | | | | | | | |
| | w | f | y | h | m | c | r | e | l | i | q | g | k | d | v | p | n | a | 26T | 1.00 | S | T | | | | | | | | | | | | | | | | | | |
| m | w | f | i | y | c | h | v | q | l | e | t | k | n | d | p | s | a | R | 27G | 1.00 | G | | | | | | | | | | | | | | | | | | | |
| w | h | y | f | n | m | d | r | q | e | k | c | i | l | p | t | s | g | V | 28A | 1.00 | A | | | | | | | | | | | | | | | | | | | |
| m | w | i | v | f | c | l | y | r | p | q | h | a | t | k | e | s | g | N | 29D | 1.00 | D | | | | | | | | | | | | | | | | | | | |
| | w | m | c | y | h | f | r | q | k | t | p | v | s | l | a | n | g | e | 30D | 1.00 | I | D | | | | | | | | | | | | | | | | | | |
| | w | f | y | h | m | c | r | e | l | i | q | g | k | d | v | p | n | a | 31T | 1.00 | S | T | | | | | | | | | | | | | | | | | | |
| | h | q | w | p | d | n | e | r | c | k | g | s | y | a | t | m | f | l | 32V | 1.00 | V | I | | | | | | | | | | | | | | | | | | |
| | | | h | d | w | q | p | e | n | c | r | s | k | g | y | a | t | m | 33L | 1.00 | F | L | V | I | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | w | y | f | c | 34E | 1.00 | m | h | i | p | v | l | G | r | N | T | d | Q | S | K | A | E | | | | |
| | | | | | | | | | | | w | c | m | f | i | y | v | l | 35E | 1.00 | h | R | t | p | s | a | k | q | n | G | D | E | | | | | | | | |
| | | | | | | | | | | | | | | | | | | w | 36M | 1.00 | c | y | f | h | p | g | r | N | l | d | q | M | s | T | K | V | A | E | I | |
| | | | | | | w | c | f | y | m | i | h | v | l | p | r | g | t | 37S | 1.00 | a | Q | K | S | N | D | E | | | | | | | | | | | | | |
| | d | h | n | e | c | k | s | r | g | q | p | t | a | y | v | m | f | i | 38L | 1.00 | W | L | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | w | 39P | 1.00 | f | m | i | y | c | h | l | v | t | e | Q | d | r | n | S | K | a | P | G | |
| | | | | | | | | | | | w | m | f | c | i | l | y | v | 40G | 1.00 | h | q | R | a | k | e | P | T | N | D | S | G | | | | | | | | |
| | | | | | | | | | | | | | | | | w | y | c | 41R | 1.00 | f | m | i | v | H | P | L | g | q | T | a | S | D | R | e | N | K | | | |
| | q | h | k | n | r | d | e | g | p | c | t | s | a | m | v | i | l | f | 42W | 1.00 | Y | W | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | w | 43K | 0.95 | c | m | p | i | h | f | g | y | n | l | d | V | a | e | Q | R | S | T | K | |
| | w | h | y | m | f | i | q | c | r | l | e | k | n | d | v | t | g | a | 44P | 1.00 | S | P | | | | | | | | | | | | | | | | | | |
| | | w | c | f | y | d | m | h | n | p | g | i | s | e | t | l | q | a | 45K | 1.00 | r | V | K | | | | | | | | | | | | | | | | | |
| | | | h | w | d | n | q | e | g | p | r | c | s | k | y | t | a | f | 46M | 1.00 | l | V | M | I | | | | | | | | | | | | | | | | |
| | h | q | w | p | d | n | e | r | c | k | g | s | y | a | t | m | f | l | 47I | 1.00 | V | I | | | | | | | | | | | | | | | | | | |
| | m | w | i | f | c | v | y | l | q | r | t | e | k | p | a | s | d | n | 48G | 1.00 | H | G | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | f | e | d | c | a | 49G | 1.00 | G | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | h | g | f | e | d | c | a | 50I | 1.00 | I | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | f | e | d | c | a | 51G | 1.00 | G | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | f | e | d | c | a | 52G | 1.00 | G | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | w | m | i | 53F | 1.00 | c | v | l | y | r | q | h | p | t | k | e | F | a | s | G | d | N | | | |
| | d | h | n | g | e | c | w | s | r | k | p | y | q | t | a | f | m | v | 54I | 1.00 | L | I | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | c | w | f | m | i | 55K | 1.00 | y | d | v | g | s | l | a | t | H | e | P | q | N | R | K | | | | | |
| | | | | w | g | h | y | d | n | r | q | f | e | k | c | p | s | l | 56V | 1.00 | a | i | M | T | V | | | | | | | | | | | | | | | |
| | c | w | f | d | m | i | y | v | p | s | h | l | n | a | t | e | q | G | 57R | 1.00 | R | K | | | | | | | | | | | | | | | | | | |
| | | c | w | f | m | i | y | v | l | h | g | n | t | s | p | r | a | d | 58Q | 1.00 | K | Q | E | | | | | | | | | | | | | | | | | |
| | | q | k | n | r | d | h | g | e | p | c | t | m | a | v | w | l | I | 59Y | 1.00 | S | F | Y | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | w | c | f | m | y | i | 60D | 1.00 | v | h | l | p | t | g | a | e | Q | S | N | R | K | D | | | | | | |
| | | | | | | m | i | w | v | f | l | c | y | r | p | a | t | h | 61Q | 1.00 | k | e | s | G | Q | D | N | | | | | | | | | | | | | |
| | | | h | w | q | d | p | n | e | c | g | s | k | y | m | f | a | t | 62I | 1.00 | l | R | I | V | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | 63L | 1.00 | c | w | m | P | i | g | n | d | v | T | H | Q | s | f | r | a | L | K | Y | E |
| | | h | q | w | p | d | n | e | c | r | k | s | g | y | a | t | m | f | 64I | 1.00 | L | V | I | | | | | | | | | | | | | | | | | |
| | | | | | | | | | w | c | f | y | m | i | h | v | l | p | 65E | 1.00 | n | t | s | a | D | R | G | Q | K | E | | | | | | | | | | |
| | | h | q | w | p | d | n | e | c | r | s | k | g | y | a | t | m | f | 66I | 1.00 | L | V | I | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | w | g | d | 67C | 1.00 | h | n | R | q | y | s | E | k | C | p | f | m | t | a | I | L | V | | | |
| | | m | i | w | v | f | l | c | y | r | p | q | a | t | h | k | e | s | 68G | 1.00 | D | N | G | | | | | | | | | | | | | | | | | |
| | | | c | w | d | f | m | i | v | g | p | s | n | a | l | t | Y | e | 69H | 1.00 | Q | H | R | K | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | c | w | d | 70K | 1.00 | f | M | y | p | G | h | s | n | t | a | V | I | l | e | q | R | K | | | |
| | | | | g | w | h | y | d | n | r | q | f | s | e | k | c | p | m | 71A | 1.00 | T | L | I | A | V | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | 72I | 1.00 | w | d | c | p | g | n | M | e | q | s | h | F | T | R | y | K | a | l | I | V |
| | w | h | y | f | i | m | q | n | d | l | e | c | k | v | t | p | s | R | 73G | 1.00 | A | G | | | | | | | | | | | | | | | | | | |
| | w | f | y | h | m | c | r | e | l | i | q | g | k | d | v | p | n | a | 74T | 1.00 | S | T | | | | | | | | | | | | | | | | | | |
| | | | | | | c | w | p | d | m | e | k | q | n | g | r | t | s | 75V | 0.95 | a | h | l | f | y | V | I | | | | | | | | | | | | | |
| | | c | w | p | d | e | k | q | n | g | r | t | i | s | v | a | h | f | 76L | 0.95 | y | M | L | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | 77V | 0.95 | c | w | p | d | m | e | k | q | n | g | r | s | a | h | f | L | y | I | T | V |
| c | w | p | d | m | e | k | q | n | r | t | i | s | v | a | h | l | f | y | 78G | 0.95 | G | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | 79P | 0.95 | c | w | m | g | n | q | i | r | e | k | t | v | h | l | f | S | A | y | D | P |
| c | w | p | d | m | e | q | k | n | g | r | i | s | v | a | h | l | f | y | 80T | 0.95 | T | | | | | | | | | | | | | | | | | | | |
| c | w | d | m | e | k | q | n | g | r | t | i | s | v | a | h | l | f | y | 81P | 0.95 | P | | | | | | | | | | | | | | | | | | | |
| | | | c | w | p | d | m | e | k | q | n | g | r | t | s | a | h | l | 82V | 0.95 | f | y | V | I | | | | | | | | | | | | | | | | |
| | c | w | p | m | e | q | k | g | r | i | t | s | v | a | h | l | f | y | 83N | 0.95 | D | N | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | h | g | f | e | d | c | a | 84I | 1.00 | I | | | | | | | | | | | | | | | | | | | |
| | | d | h | g | n | e | c | s | r | k | p | w | q | t | y | a | m | v | 85I | 1.00 | L | F | I | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | f | e | d | c | a | 86G | 1.00 | G | | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | q | p | n | m | l | k | i | h | g | f | e | d | c | a | 87R | 1.00 | R | | | | | | | | | | | | | | | | | | | |
| | m | i | w | v | f | l | c | y | r | p | q | a | h | t | k | e | s | g | 88N | 1.00 | D | N | | | | | | | | | | | | | | | | | | |
| | | | | | d | h | g | n | e | w | s | r | k | p | y | q | t | a | 89L | 1.00 | M | F | V | C | I | L | | | | | | | | | | | | | | |
| | d | h | g | n | e | c | s | w | r | k | y | p | q | t | a | f | v | i | 90L | 1.00 | M | L | | | | | | | | | | | | | | | | | | |
| | | | | | | w | f | c | y | m | h | i | l | v | p | r | g | k | 91T | 0.97 | d | s | N | Q | E | A | T | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | w | 92Q | 0.97 | f | y | c | m | h | i | l | v | P | n | d | T | r | G | e | s | Q | K | A | |
| | | | | d | h | g | n | e | c | s | w | y | r | k | p | q | t | f | 93I | 0.97 | v | M | A | I | L | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | f | e | d | c | a | 94G | 0.97 | G | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | w | h | 95C | 0.97 | y | n | d | q | r | e | k | f | C | i | M | t | v | p | L | s | G | A | | |
| | | | | | | | | | | | w | f | c | m | y | i | h | d | 96T | 0.97 | g | v | l | p | e | n | a | q | R | K | S | T | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | k | i | h | g | f | e | d | c | a | 97L | 0.97 | L | | | | | | | | | | | | | | | | | | | |
| | w | m | f | y | c | h | q | r | i | p | e | k | l | t | d | s | a | g | 98N | 0.82 | V | N | | | | | | | | | | | | | | | | | | |
| y | w | v | t | s | r | q | p | n | m | l | k | i | h | g | e | d | c | a | 99F | 0.50 | F | | | | | | | | | | | | | | | | | | | |